Cannabis and the Incidence of Psychotic Disorder – A Multi-cohort Study

While cannabis (Cannabis sativa, Cannabaceae) prohibition is being discarded by many nations, epidemiological studies and biological evidence continue to report links between its use and psychotic disorder (PD). A meta-analysis reported a dose-response link, with the highest risks of PD among people with heaviest cannabis use. It is unclear whether cannabis use affects the incidence … Continue reading Cannabis and the Incidence of Psychotic Disorder – A Multi-cohort Study

Cannabis Decoction as an Adjuvant in the Management of Chronic Pain

Chronic pain, poorly managed by conventional medicine, afflicts one in five Europeans, with a significant impact on the quality of life (QoL). Depression, anxiety, and sleep disorders are common results of chronic pain. A survey of chronic pain sufferers revealed that one-third had tried three or more prescription treatments but more than 50% only obtained … Continue reading Cannabis Decoction as an Adjuvant in the Management of Chronic Pain

Regulatory Framework for the Expanding US Cannabis Industry Proposed in HerbalGram Article

Austin, TX (July 23, 2019). The current issue of the nonprofit American Botanical Council’s (ABC’s) peer-reviewed journal HerbalGram features a proposed state-federal regulatory framework for the US cannabis (Cannabis sativa) industry.1 The proposal suggests the removal of cannabis from the Controlled Substances Act (CSA), thus allowing US stakeholders entry into the global market. The US state-led regulated hemp and cannabis … Continue reading Regulatory Framework for the Expanding US Cannabis Industry Proposed in HerbalGram Article

Cannabis Alleviates Anxiety, Depression and Pain in Patients Newly Diagnosed with Head and Neck Cancer

In October 2018, Canada became the third nation, and the world's largest to date, to legalize adult ("recreational") use of cannabis (marijuana; Cannabis sativa, Cannabaceae). While hinting at this development, the authors write that cannabis is "one of the most widely used illicit substance in Canada, [with] a unique ability to facilitate relaxation and relieve anxiety … Continue reading Cannabis Alleviates Anxiety, Depression and Pain in Patients Newly Diagnosed with Head and Neck Cancer

Cannabinoids for Chemotherapy-induced Nausea and Vomiting: Overview of Systematic Reviews

Chemotherapy-induced nausea and vomiting (CINV), one of the most distressing chemotherapy-related adverse events (AEs), affects about 75% of patients undergoing chemotherapy. Antiemetic drugs are considered first-line treatments, while cannabinoids are considered an option to be used if other antiemetics fail. The cannabinoids used for CINV include tetrahydrocannabinol (THC) and analogs of THC. The US Food … Continue reading Cannabinoids for Chemotherapy-induced Nausea and Vomiting: Overview of Systematic Reviews

Cannabis: Answer to The Opioid Crisis?

Opioid drugs* like oxycodone, hydrocodone, methadone, and heroin caused over 28,000 deaths in the United States in 2014, more than any earlier year on record, according to the Centers for Disease Control and Prevention (CDC). It was estimated in 2012 that about 2.1 million Americans suffered substance abuse disorders related to prescribed opioids and another … Continue reading Cannabis: Answer to The Opioid Crisis?

Breeding Cannabis Chemovars for Patients Requiring Distinct Chemical Profiles for Optimum Efficacy

Proper exposition requires definition, certainly the case in the longstanding debate over cannabis (Cannabis sativa, Cannabaceae) speciation. Authors briefly introduce the ongoing dispute between followers of Fuchs (1542 CE) and Linnaeus (1753) and those of Lamarck (1783) and Schultes (1974). Lamarck described the putative "C. indica" and has been followed by proposed “compromise” naming like … Continue reading Breeding Cannabis Chemovars for Patients Requiring Distinct Chemical Profiles for Optimum Efficacy

Administration and Dosing of Medical Cannabis

Despite centuries of medical use and several modern studies, 80 years of cannabis (Cannabis sativa, Cannabaceae) prohibition have left clinicians undereducated about its therapeutic uses. A 2017 US study found that 89.5% of surveyed residents and fellows felt unprepared to prescribe cannabis and just 35.5% felt prepared to answer patients' questions about it. Only 9% … Continue reading Administration and Dosing of Medical Cannabis

Study Finds Cannabidiol Reduces Frequency of Convulsive Seizures in Children and Young Adults with Dravet Syndrome

Dravet syndrome, a rare genetic childhood epilepsy associated with drug-resistant seizures and high mortality, may be amenable to treatment with cannabidiol (CBD), a constituent of cannabis (Cannabis sativa, Cannabaceae). While 4 small trials reported mixed results, in vitro and in vivo models show antiseizure activity. A standardized oral solution of CBD (prepared and provided by … Continue reading Study Finds Cannabidiol Reduces Frequency of Convulsive Seizures in Children and Young Adults with Dravet Syndrome