Category Archives: Apple Extract Does Not Improve Flow-mediated Vasodilation in Subjects with Borderline or Mild Hypertension

Apple Extract Does Not Improve Flow-mediated Vasodilation in Subjects with Borderline or Mild Hypertension

Elevated blood pressure (BP) or hypertension causes endothelial dysfunction and increases the risk of coronary heart disease. In experimental models, epicatechin (a flavan-3-ol flavonoid) has been shown to have cardioprotective effects by activating endothelial nitric oxide synthase (eNOS) and improving endothelial function. The purpose of this single-center, repeated-dose, double-blind, placebo-controlled, crossover study was to test the hypothesis that an apple (Malus

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